Automating the creation of dose escalation safety summary reports for Phase I trials

Written By Steffan Stringer

From eSource right through to Safety Summary Report

Introduction

I have reworked an old presentation that I sweated over profusely at the time, staying up late and sober to finish it off, whilst my colleagues were having one last drink.

It made sense to me, but I am not sure it made sense to anybody else.

I think I struggled, not being a data scientist, but being familiar with the problem space.

Things have moved on surprisingly quickly since that day in Chicago in 2017 with analytical tools such as as R, Python and Jupyter becoming trusted and more prevalent.

The newer open source Quarto project seems particularly interesting compared to R Markdown / R Studio, as it is mulitlingual.

So I have had another go and have tried to strip it down to the basics.

Did I pare it down too much?

Does it make any more sense now?

Does your Phase I Unit do this already? Am I now soooo out of touch? 😄

If so, tell me all about it!

Download a PDF copy here.

This presentation has been carefully crafted using Deckset with Markdown and Mermaid.

Sadly, it has not been committed to a git repo, but I am more than happy to share the source code 😈

Links from the report

Steffan Stringer
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